SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent mannerSARS-CoV-2 슈도바이러스는 Arf6 의존적 방식으로 스파이크 단백질-CD147을 통해 숙주 세포에 들어갑니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach Arf6 blockade CD147 cells clathrin Clathrin-mediated endocytosis clinically coronavirus endocytic endocytic mechanism endocytosis evaluate feasible function host cell host cells Huh-7 cell Huh-7 cells independent independent of indicated infected Vero E6 cells Infection inhibited inhibitor knockdown Localization macropinocytosis pathway Prevent pseudovirus pseudovirus infection public health RAB5A SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus infection severe acute respiratory syndrome Coronavirus Spike protein spike protein. Spread the SARS-CoV-2 variant Vero E6 VERO E6 cells viral infection weakened [DOI] 10.1080/22221751.2022.2059403 PMC 바로가기 [Article Type] Article
An engineered 5-helix bundle derived from SARS-CoV-2 S2 pre-binds sarbecoviral spike at both serological- and endosomal-pH to inhibit virus entrySARS-CoV-2 S2에서 파생된 조작된 5나선 번들은 바이러스 진입을 억제하기 위해 혈청학적 pH와 엔도솜 pH 모두에서 사베코바이러스 스파이크를 사전 결합합니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] 5-helix bundle (5HB) acute respiratory syndrome acute respiratory syndrome coronavirus bind binding Broad-spectrum inhibition can not cell membrane construction coronavirus Evidence feature fusion heptad repeat highlighting host cell host cells IC50 infections inhibit neutralize peptide peptides pre-fusion predominant Protein sarbecovirus sarbecovirus Sarbecoviruses SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 S2 SARS-CoV-2 variant SARS-CoV-2 variants serological severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 structural basis These data Treatment viral entry viral entry. viral spike virus entry virus infection [DOI] 10.1080/22221751.2022.2095308 PMC 바로가기 [Article Type] Article
Heterologous booster with inhaled adenovirus vector COVID-19 vaccine generated more neutralizing antibodies against different SARS-CoV-2 variantsArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] addition adenoviral vector Adenovirus adenovirus type 5 vector vaccine Anti-RBD IgG booster COVID-19 COVID-19 vaccine D614G demonstrated dose effective Efficacy IgA immunization Inactivated vaccine Inactivated Vaccines Inhaled lack mucosal Neutralization assay Neutralizing neutralizing antibody omicron Omicron variant BA.5 pandemic plasma Protective RBD SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 vaccines SARS-CoV-2 variant subunit titre Vaccination strategies vaccination strategies. Vaccination strategy Vaccine variant virus widespread [DOI] 10.1080/22221751.2022.2132881 PMC 바로가기
Antigen-adjuvant interactions, stability, and immunogenicity profiles of a SARS-CoV-2 receptor-binding domain (RBD) antigen formulated with aluminum salt and CpG adjuvantsArticle Published on 2022-11-302022-11-15 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 진단, [키워드] abrogated ACE2 addition adjuvant adjuvants Adsorption alum aluminum analysis Antigen approach binding booster Combination Complete conformational Coverage COVID-19 COVID-19 vaccine CpG decrease demonstrated destabilized domain dose ELISA exacerbated facilitate Formulation highlight host cell receptor immune responses immunogenicity IMPROVE in vitro in vivo Interaction interactions mice neutralize neutralizing antibody profile Protein RBD RBD antigen SARS-CoV-2 SARS-CoV-2 pseudovirus spike stability stability profile subunit vaccines temperature the receptor-binding domain Vaccine vaccine. while [DOI] 10.1080/21645515.2022.2079346 PMC 바로가기
Ganoderma microsporum immunomodulatory protein acts as a multifunctional broad-spectrum antiviral against SARS-CoV-2 by interfering virus binding to the host cells and spike-mediated cell fusionArticle Published on 2022-11-012022-11-15 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS, 변종, 치료제, [키워드] ACE2 ACE2-expressing cells acute respiratory syndrome alleviate Antiviral binding blocked Broad-spectrum antiviral against SARS-CoV-2 caused Cell Cell fusion cell lines cell-free virus cells characteristic coronavirus Delta determine Diseases downregulation Effect evaluated examined flow cytometry fluorescence microscopy fluorescent Fungal immunomodulatory proteins fusion GMI HEK293T cell host cell immunomodulatory immunoprecipitation in vitro Infection Infectivity ingredient inhibit inhibited inhibitor Interaction investigated less mechanism multifunctional omicron Protein pseudotyped virus reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus infection SARS-CoV-2 spike protein SARS-CoV-2 variant spike mutation spike variant spike variants Strains Viral binding. virus were used [DOI] 10.1016/j.biopha.2022.113766 PMC 바로가기
Rapid and universal detection of SARS-CoV-2 and influenza A virus using a reusable dual-channel optic fiber immunosensorArticle Published on 2022-11-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 신종인플루엔자, 치료기술, [키워드] clinical sample colloidal gold Delta demonstrated detect dual-channel optic fiber immunosensor enzyme-linked immunosorbent Evanescent fiber H1N1 H3N2 H7N9 Infectious disease influenza A influenza A virus influenza A virus limit of detection linear mobile phase detection. much higher omicron optical pathogenic viruses platform presenting Rapid Real-time monitoring respond SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 pseudovirus sensitivity specificity Strains Surveillance TCID the epidemic the SARS-CoV-2 the spike protein variants viruses [DOI] 10.1002/jmv.28015 PMC 바로가기
Postvaccination anti-S IgG levels predict anti-SARS-CoV-2 neutralising activity over 24 weeks in patients with RAArticle Published on 2022-10-012022-11-15 Journal: RMD Open [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] Analysis anti-S IgG level anti-SARS-CoV-2 anti-SARS-CoV-2 vaccine antiviral activity assessment benefit comparable correlation COVID-19 declined demonstrated HCs healthy control identify IFN-γ ELISPOT IgA IgG IgG antibody IgG level IgG response IgM isotype IgM response IgM responses immune response mRNA neutralisation assay neutralisation assays neutralising Neutralising activity Patient performed potent predict Prophylactic Receptor binding domain regimen response Rheumatoid rheumatoid arthritis SARS-CoV-2 SARS-CoV-2 pseudovirus T cell response titre two-dose regimen vaccination. vaccine dose Viral protein [DOI] 10.1136/rmdopen-2022-002575 PMC 바로가기
SARS-CoV-2 spike protein enhances MAP4K3/GLK-induced ACE2 stability in COVID-19Article Published on 2022-09-072022-10-06 Journal: EMBO Molecular Medicine [Category] COVID19(2023년), SARS, 진단, [키워드] ACE2 ACE2 protein cells contribute correlated COVID-19 COVID-19 cohort Degradation E3 ligase ENhance entry receptor epithelial epithelial cell epithelial cells Exosome Exosomes humanized Infection Live virus lysine MAP4K3/GLK mice overexpression pathogenesis of COVID-19 patients phosphorylated prevented pseudovirus infection residue RNA-sequencing SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 spike SARS-CoV-2 spike protein secretion Serine serum exosome severity stability the SARS-CoV-2 transported UBR4 UBR4. Vesicle with COVID-19 [DOI] 10.15252/emmm.202215904 PMC 바로가기 [Article Type] Article
Immunomolecular assay based on selective virion capture by spike antibody and viral nucleic acid amplification for detecting intact SARS-CoV-2 particlesArticle Published on 2022-09-052022-11-15 Journal: Journal of Nanobiotechnology [Category] SARS, 치료기술, [키워드] Accuracy acute respiratory syndrome aluminum amplification analyses antibody applied Characteristics clinical sample coefficient Complete Complete virions conditions convalescent coronavirus coronavirus disease COVID-19 Critical detect diagnose facilitate Factor glycoprotein Human immunodeficiency virus human serum Immune escape Immunomolecular detection IMPROVE infection risk Influenza isolation rooms limit of detection molecular monoclonal antibody Mutation nucleic acid amplification Outbreaks parameters Patient pseudovirus quantified Quantitative reduced reverse transcription PCR reverse transcription-PCR SARS-CoV-2 SARS-CoV-2 particle SARS-CoV-2 pseudovirus selective specific antibodies spike Spike. stability Vaccine Variation Viral load viral nucleic acid viral spike viral titer virion virions virus virus detection virus isolation viruses [DOI] 10.1186/s12951-022-01558-8 PMC 바로가기
Structures, biomimetic synthesis, and anti-SARS-CoV-2 activity of two pairs of enantiomeric phenylpropanoid-conjugated protoberberine alkaloids from the rhizomes of Corydalis decumbensArticle Published on 2022-09-012022-11-15 Journal: Archives of pharmacal research [Category] SARS, 치료제, [키워드] ACE2 receptor analyses Analysis anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Antiviral binding Biomimetic synthesis biosynthetic Compound Corydalis Corydalis decumbens COVID-19 ECD exhibited ferulic acid host cells HPLC Isoquinoline alkaloid. Pathways purified SARS-CoV-2 pseudovirus Structure X-ray [DOI] 10.1007/s12272-022-01401-6 PMC 바로가기